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THE CENTRE FOR INFECTIOUS DISEASE RESEARCH IN ZAMBIA (CIDRZ), TOGETHER WITH THE ASSOCIATION OF PUBLIC HEALTH LABORATORIES (APHL), WITS HEALTH CONSORTIUM (WHC), CLINICAL AND LABORATORY STANDARDS INSTITUTE (CLSI) AND FIND DIAGNOSTICS HAVE ESTABLISHED A CONSORTIUM TO SUPPORT ‘TRANSITIONING AND INTEGRATING LABORATORY SERVICES FOR HIGH QUALITY HIV DIAGNOSIS, CARE, TREATMENT, AND MONITORING TO THE MINISTRY OF HEALTH (MOH) TO SUSTAIN ACHIEVEMENT OF THE 95-95-95 GOALS IN ZAMBIA UNDER PEPFAR’. EFFECTIVE AND EFFICIENT DISEASE DIAGNOSTICS ARE AN ESSENTIAL COMPONENT OF ANY RESILIENT HEALTH SYSTEM. STRONG LABORATORY (LAB) DIAGNOSTIC CAPACITY IS IMPORTANT FOR DISEASE SURVEILLANCE, DIAGNOSIS, PREVENTION, TREATMENT, HEALTH PROMOTION NOW MORE THAN EVER, GIVEN THE MYRIAD OF POTENTIAL GLOBAL HEALTH THREATS. LABS ARE A CRITICAL COMPONENT IN ACHIEVING THE UNAIDS 95-95-95 TARGETS TO HAVE AN AIDS-FREE GENERATION, RESPOND TO EMERGING PATHOGENS AND PROVIDE OPTIMAL CARE FOR HIV+ INDIVIDUALS. OVER THE PAST DECADE, TREMENDOUS EFFORTS HAVE BEEN MADE TO DEVELOP AND STRENGTHEN LAB SYSTEMS TO ADEQUATELY RESPOND TO THE SCALE UP OF THE ART PROGRAM IN PEPFAR COUNTRIES AND ADAPT THESE TO HEALTH CHALLENGES; HOWEVER, SEVERAL BARRIERS PERSIST IN CREATING SUSTAINABLE, ACCESSIBLE, AND EFFICIENT HIGH-QUALITY SYSTEMS THAT GOVERNMENTS CAN ADMINISTER WITH MINIMAL EXTERNAL SUPPORT. ZAMBIA CONTINUES TO MAKE PROGRESS TOWARDS ENDING THE AIDS EPIDEMIC BY 2030 BY ADOPTING THE 95-95-95 TARGETS. THE COUNTRY HAS ATTAINED THE SECOND (98%) AND THIRD (96.3%) TARGET AMONG PERSONS >=15 YEARS OF AGE. DESPITE THESE REMARKABLE ACCOMPLISHMENTS, CHALLENGES REMAIN IN ATTAINING THE FIRST TARGET AMONG ADULTS, FOR CHILDREN <15 YEARS AND KEY AND PRIORITY POPULATIONS ACROSS ALL THREE TARGETS. ADDRESSING THE REMAINING PROGRAMMATIC CHALLENGES IN DIAGNOSIS, TREATMENT, ADHERENCE, AND FULL GOVERNMENT IMPLEMENTATION OF THE HEALTH SYSTEM WILL ACCELERATE ZAMBIA’S ATTAINMENT OF THE UNAIDS AND PEPFAR GOALS. OUR CONSORTIUM HAS OVER 20 YEARS OF COMBINED INSTITUTIONAL EXPERIENCE IN ZAMBIA AND THE SUB-REGION TO EXPAND HIV PREVENTION, CARE AND TREATMENT SERVICES INCLUDING LAB SYSTEMS STRENGTHENING. MORE SPECIFICALLY, WE HAVE MENTORED LABS TO ACHIEVE INTERNATIONAL ISO15189 ACCREDITATION, PROVIDED TECHNICAL AND MATERIAL SUPPORT TO ESTABLISH AND IMPROVE INTEGRATED SAMPLE COURIER NETWORKS, DIGITAL SAMPLE REFERRAL AND RESULTS RETURN, WASTE MANAGEMENT, BACKUP POWER SYSTEMS AND ASSISTED GOVERNMENT TO FIND GAPS AND FIX THEM AT ALL LEVELS OF LAB OPERATIONS. OUR CONSORTIUM WILL IMPLEMENT PROVEN STRATEGIES THAT INCLUDE THE DEVELOPMENT AND SHARING OF POLICIES AND GUIDANCE, AND IMPLEMENTATION OF ACTIVITIES THAT: 1) MAINTAIN CONTINUITY WITH PRIOR LAB STRENGTHENING EFFORTS IN DIGITAL SAMPLE REFERRAL AND RESULTS RETURN, INTEGRATED SAMPLE COURIER SYSTEMS, QUALITY MANAGEMENT SYSTEMS, MEDICAL WASTE MANAGEMENT, POWER BACKUP AND OTHER GAPS IN THE LAB VALUE CHAIN; 2)PROVIDE TECHNICAL ASSISTANCE (TA) TO ACHIEVE FULL SYSTEM FUNCTIONALITY AT ALL LEVELS OF THE LAB NETWORK FROM FACILITY TO NATIONAL LEVEL; 3) CONDUCT CAPACITY ASSESSMENT OF PARTNER-SUPPORTED LAB SYSTEMS INCLUDING COSTING REQUIRED TO MAINTAIN LAB SERVICES, AND 4) TRANSITION LAB SERVICES TO FULL GOVERNMENT CONTROL THROUGH A STEPWISE TRANSITION APPROACH FOR MOH IMPLEMENTATION AND OVERSIGHT. OUR APPROACH IS ANCHORED IN PROVEN EXPERIENCE BUILDING AND STRENGTHENING PUBLIC -PRIVATE PARTNERSHIPS, PROMOTING COUNTRY OWNERSHIP/ LEADERSHIP, AND PROVIDING KNOWLEDGE AND MATERIAL SUPPORT TO GOVERNMENT TECHNICAL WORKING GROUPS TO DEVELOP POLICIES FOR INCREASED ACCESS TO HIGH QUALITY LAB TESTING. OUR CONSORTIUM HAS ALSO BEEN ABLE TO EMPOWER GOVERNMENT STAFF TO SUPPORT THE INTEGRATION OF LAB SERVICES AND SYSTEMS, TRAINING, AND LOGISTICS. OUR CONSORTIUM WILL WORK COLLABORATIVELY WITH THE ZAMBIAN GOVERNMENT THROUGH THE MOH AND OTHER STAKEHOLDERS TO ACHIEVE OUR VISION OF A RESILIENT AND SUSTAINABLE HIGH-QUALITY NATIONAL LABORATORY NETWORK FULLY MANAGED BY THE ZAMBIAN GOVERNMENT."},{"date":"3/23/2025","agency":"Department of Health and Human Services","recipient":"HEALTH AND HUMAN SERVICES, NEBRASKA DEPARTMENT OF","value":468645,"savings":108346,"link":null,"description":"NEBRASKA 2019 EPIDEMIOLOGY AND LABORATORY CAPACITY FOR PREVENTION AND CONTROL OF EMERGING INFECTIOUS DISEASES (ELC)"},{"date":"3/23/2025","agency":"Department of Health and Human Services","recipient":"JOHNS HOPKINS UNIVERSITY","value":3341842,"savings":106473,"link":null,"description":"Enhancing Global Health Security: Expanding Efforts and Strategies to Protect and Improve Public Health Globally"},{"date":"3/23/2025","agency":"Department of Health and Human Services","recipient":"PUBLIC HEALTH AND ENVIRONMENT, COLORADO DEPARTMENT OF","value":1000000,"savings":103858,"link":null,"description":"Advancing the Centers of Excellence in Newcomer Health"},{"date":"3/23/2025","agency":"Department of Health and Human Services","recipient":"UTAH DEPARTMENT OF HEALTH AND HUMAN SERVICES","value":540416,"savings":102940,"link":null,"description":"UTAH'S PROPOSAL FOR ACTIVITIES WITHIN THE 2020 EPIDEMIOLOGY AND LABORATORY CAPACITY FOR PREVENTION AND CONTROL OF EMERGING INFECTIOUS DISEASES (ELC) COOPERATIVE AGREEMENT"},{"date":"3/23/2025","agency":"Department of Health and Human Services","recipient":"COUNCIL OF STATE & TERRITORY EPIDEMIOLOGISTS","value":2365061,"savings":102885,"link":null,"description":"CATEGORY B: PROVIDING CAPACITY BUILDING ASSISTANCE TO STATE, TRIBAL, LOCAL AND TERRITORIAL APPLIED EPIDEMIOLOGISTS"},{"date":"3/23/2025","agency":"Department of Health and Human Services","recipient":"REPUBLIC OF THE MARSHALL ISLANDS, HEALTH SERVICES","value":654603,"savings":102882,"link":null,"description":"RMI National Initiative to Address COVID-19 Health Disparities Among Populations at High-Riskand Undeserved, Including Racial and Ethnic Minority Populations and Rural Communities"},{"date":"3/23/2025","agency":"Department of Health and Human Services","recipient":"AMERICAN PHARMACEUTICAL ASSOCIATION","value":1250000,"savings":102484,"link":null,"description":"Optimization of the Pharmacist's Role to Prevent and Control Emerging and Re-Emerging Infectious Disease Threats"},{"date":"3/23/2025","agency":"Department of Health and Human Services","recipient":"STATE OF GEORGIA DEPARTMENT OF PUBLIC HEALTH","value":355876,"savings":102119,"link":null,"description":"CK19-1904 EPIDEMIOLOGY AND LABORATORY CAPACITY FOR PREVENTION AND CONTROL OF EMERGING INFECTIOUS DISEASES (ELC)"},{"date":"3/23/2025","agency":"Department of Health and Human Services","recipient":"GU DEPARTMENT OF PUBLIC HEALTH & SOCIAL SERVICE","value":150000,"savings":100585,"link":null,"description":"Guam IP19-1901 Immunization and Vaccines for Children Program, IIS Supplemental"},{"date":"3/23/2025","agency":"Department of Health and Human Services","recipient":"FEDERATED STATES OF MICRONESIA, OFFICE OF HEALTH SVCS","value":100000,"savings":100000,"link":null,"description":"CDC-RFA-IP19-1901 Immunization and Vaccines for Children 2023 Supplemental Funds"},{"date":"3/23/2025","agency":"Department of Health and Human Services","recipient":"REPUBLIC OF THE MARSHALL ISLANDS, HEALTH SERVICES","value":100000,"savings":100000,"link":null,"description":"CDC-RFA-IP19-1901 Immunization and Vaccines for Children"},{"date":"3/23/2025","agency":"Department of Health and Human Services","recipient":"REPUBLIC OF PALAU, BUREAU OF HEALTH SEVICES","value":100000,"savings":100000,"link":null,"description":"Immunization Program Cooperative Agreement for Palau Ministry of Health, Bureau of Public Health: BY5 application revisions"},{"date":"3/23/2025","agency":"Department of Health and Human Services","recipient":"ALBERT EINSTEIN COLLEGE OF MEDICINE","value":7100728,"savings":3242942,"link":null,"description":"EINSTEIN BSL3 LABORATORY RENOVATION TO ADVANCE BIOMEDICAL RESEARCH ON RNA VIRUSES OF PANDEMIC POTENTIAL - ABSTRACT WE PROPOSE TO RENOVATE EXISTING LABORATORY SPACE IN THE CHANIN BUILDING AT THE ALBERT EINSTEIN COLLEGE OF MEDICINE (EINSTEIN) WHICH WILL EXPAND AND IMPROVE AVAILABLE BSL-3 AND ABSL-3 FACILITIES TO SERVE THE GROWING NEEDS OF OUR EINSTEIN INVESTIGATORS WHO CONDUCT RESEARCH ON EMERGING RNA VIRUSES WITH THE ULTIMATE GOAL OF VACCINE AND THERAPEUTICS DEVELOPMENT. OUR CURRENT SMALL VIROLOGY BSL-3 FACILITY LACKS THE SPACE TO MEET CURRENT AND PROJECTED INVESTIGATOR DEMAND AND TO HOUSE THE EQUIPMENT NEEDED TO CONDUCT CUTTING-EDGE IN VITRO AND CELL-BASED STUDIES AND WORK WITH ANIMALS. IN ADDITION TO RENOVATION THAT INCLUDES EXPANDED BSL-3 AND ABSL-3 SPACE (1497 SQ FT SPECIFICALLY FOR RNA VIRUS RESEARCH), OUR PLAN INCLUDES MODERNIZATION OF BUILDING SYSTEMS AND INVESTMENTS IN FIXED EQUIPMENT AND NOVEL NONFIXED SCIENTIFIC EQUIPMENT TO ENHANCE AND STREAMLINE LABORATORY OPERATIONS. FURTHER, THE EXISTING BSL-3 SPACE IN CHANIN HAS TEMPERATURE CONTROL SYSTEMS WHICH ARE INADEQUATE AND SORELY IN NEED OF UPDATING; THIS WILL BE ALLEVIATED BY NEW AND INDEPENDENT SYSTEM FOR TEMPERATURE, HUMIDITY AND EXHAUST (DEDICATED AND REDUNDANT). WE THEREFORE REQUEST SUPPORT FOR THE FOLLOWING AIMS, WHICH ARE INTENDED TO EXPAND AND UPGRADE OUR EXISTING FACILITY, WITH NEW TECHNOLOGIES FOR LABORATORY SUPPORT, ANIMAL HOLDING, AND ENERGY EFFICIENCY. IN THE FOLLOWING SECTIONS, WE DESCRIBE AN OVERSIGHT PROCESS THAT WILL FACILITATE ALL ASPECTS OF THE RENOVATION PROCESS. AIM 1. MODERNIZE AND EXPAND OVERALL BSL-3 SPACE IN THE CHANIN BUILDING FOR EMERGING RNA VIRUS RESEARCH. AIM 2. CREATE INFRASTRUCTURE FOR ANIMAL VIRUS STUDIES AT THE BSL-3 LEVEL. AIM 3. FURNISH THE RENOVATED LABORATORY SPACE WITH FIXED EQUIPMENT AND NOVEL NONFIXED SCIENTIFIC EQUIPMENT TO RESULT IN A FULLY EQUIPPED EMERGING RNA VIRUS BSL-3 LABORATORY SPACE. THIS PROPOSAL INCLUDES INSTITUTIONAL SUPPORT TO SIGNIFICANTLY SUPPLEMENT LAB EQUIPMENT FOR THIS PROJECT, ENSURE ONGOING MAINTENANCE OF ALL EQUIPMENT AND INFRASTRUCTURE IMPROVEMENTS, AND PROVIDE NEEDED PERSONNEL SUPPORT. FINALLY, EINSTEIN IS COMMITTING PILOT FUNDING TO ENABLE MORE INVESTIGATORS TO UTILIZE THE NEW FACILITY AND OBTAIN DATA TO SUPPORT GRANT APPLICATIONS TO FUND STUDIES ON RNA VIRUSES WITH PANDEMIC POTENTIAL."},{"date":"3/23/2025","agency":"Department of Health and Human Services","recipient":"AMERICAN TYPE CULTURE COLLECTION","value":3862721,"savings":893101,"link":null,"description":"ATCC'S HIGH CONTAINMENT FACILITY RENOVATIONS IN SUPPORT OF NIAID AND PANDEMIC PREPAREDNESS - PROJECT SUMMARY: THE PROPOSED PROJECT AIMS TO RENOVATE ATCC'S HIGH CONTAINMENT FACILITY (HCF) AT THE AMERICAN TYPE CULTURE COLLECTION (ATCC) IN MANASSAS, VIRGINIA. ATCC'S 7,500 FT2 BIOCONTAINMENT FACILITY WAS BUILT IN 2007 WITH FUNDING FROM NIAID AND HAS BEEN DEDICATED TO DEVELOPING INFECTIOUS DISEASE STRAINS AND REAGENTS NEEDED TO RAPIDLY ADVANCE DIAGNOSTICS, VACCINES, AND THERAPEUTICS AGAINST PRIORITY PATHOGENS. SINCE 2003, ATCC HAS PARTNERED WITH NIAID TO CENTRALIZE AND PROVIDE CRITICAL SCIENTIFIC RESOURCES THROUGH THE BIODEFENSE AND EMERGING INFECTIONS RESOURCES (BEI RESOURCES) PROGRAM. THE NIAID ESTABLISHED BEI RESOURCES TO PROVIDE THE GLOBAL RESEARCH COMMUNITY WITH REAGENTS, TOOLS, AND INFORMATION FOR STUDYING CATEGORY A, B, AND C PRIORITY PATHOGENS, EMERGING INFECTIOUS DISEASE AGENTS, AND OTHER MICROBIOLOGICAL MATERIALS RELEVANT TO HUMAN HEALTH. OVER THE PAST 18 YEARS, ATCC HAS PROVIDED OVER 1,360,000 REAGENTS TO OVER 14,000 INVESTIGATORS AT 3,740 INSTITUTIONS IN 119 COUNTRIES SPANNING OVER 500 HUMAN PATHOGENS IN NIAID'S PRIORITY PORTFOLIO. DURING THIS PERIOD, BEI RESOURCES HAS PROVIDED CRITICAL MATERIALS FOR VITAL DISEASE OUTBREAKS, INCLUDING H1N1, MERS, EBOLA, AND ZIKA. OVER THE PAST TWO YEARS, ATCC HAS RAPIDLY CREATED MORE THAN 690 SARS-COV-2 PRODUCTS; ACQUIRED, PRODUCED, AND AUTHENTICATED MORE THAN 165 STOCKS OF SARS-COV-2 FOR BOTH GENERAL RESEARCH AND CHALLENGE STUDIES; AND SHIPPED MORE THAN 86,000 RESEARCH REAGENTS TO OVER 2,800 RESEARCHERS IN MORE THAN 70 COUNTRIES FOR THE DEVELOPMENT OF COUNTERMEASURES AND BASIC RESEARCH. THE MATERIAL PROVIDED BY BEI RESOURCES HAS BEEN CITED IN MORE THAN 1,800 SARS-COV-2 PUBLICATIONS SINCE FEBRUARY OF 2020. IN ADDITION, ATCC HAS FOSTERED COLLABORATION AND PARTNERSHIPS ACROSS NIAID PROGRAMS AND EXTERNAL WORKING GROUPS TO SHARE RESOURCES, INFORMATION, AND DATA TO ACCELERATE DISCOVERIES AND HARMONIZE SCIENTIFIC APPROACHES FOR PANDEMIC RESPONSE AND PREPAREDNESS. ATCC'S HIGH CONTAINMENT FACILITY HOUSES LABORATORIES ESSENTIAL FOR BSL-3 AND SELECT AGENT INFECTIOUS DISEASE RESEARCH, PRODUCT DEVELOPMENT, AND LARGE-SCALE REAGENT PRODUCTION FOR THE RESEARCH COMMUNITY. THIS PROPOSAL AIMS TO RENOVATE AND UPGRADE THE HVAC, DECONTAMINATION, AND SECURITY SYSTEMS. THE RENOVATIONS ALSO INCLUDE UPGRADES TO FIXED EQUIPMENT AND INTERIOR FINISHING IN THE FACILITY. THE RENOVATIONS WILL MODERNIZE THE FACILITY FOR USE BY 40 PH.D. ATCC SCIENTISTS, COLLABORATORS, AND LABORATORY SUPPORT STAFF. THE PRODUCTS AND SERVICES DEVELOPED IN THE FACILITY WILL SUPPORT THOUSANDS OF SCIENTISTS GLOBALLY EACH YEAR TO PREPARE AND RESPOND TO PANDEMICS. ATCC IS SEEKING THIS OPPORTUNITY FOR ENGAGEMENT WITH THE NIAID TO INVEST IN THIS FACILITY WHICH HAS BEEN FOUNDATIONAL FOR THE NATION'S PANDEMIC RESPONSE AND PREPAREDNESS."}]},"meta":{"total_results":15887,"pages":159}}